The goal is to develop unique connectors for medical devices for each delivery system so that their inherent design makes it virtually impossible to connect unrelated systems. The new tubing connector designs are based on human factors engineering and computer aided design (CAD) analysis to reduce the likelihood of misconnections. The proposed unique designs for the connectors go through a rigorous process to ensure they connect only to the proper mating connector. Proposed designs are validated through hands-on usability testing to confirm that they meet their intended purpose of preventing the connection of a medical device from one delivery system to a device of another delivery system. Analysis of design drawings and physical force fit testing are used to verify that connectors that are supposed to connect do so securely, while connectors that should not join are physically prevented from doing so.